Glucovance 500mg/2.5mg – Combination Oral Anti-Diabetic Therapy (30 Tablets)
Glucovance 500mg/2.5mg combines two effective anti-diabetic agents—Metformin Hydrochloride (500mg) and Glibenclamide (2.5mg)—to help manage type 2 diabetes mellitus in adults. This dual-action formulation improves insulin sensitivity and promotes insulin release from the pancreas, offering comprehensive blood sugar control.
Ingredients
- Active Ingredients:
- Metformin Hydrochloride – 500mg
- Glibenclamide – 2.5mg
- Excipients: May include povidone, magnesium stearate, cellulose, and film-coating agents (refer to packaging insert for full details).
Key Benefits
- Combines two complementary mechanisms for effective blood sugar control
- Improves insulin sensitivity and reduces hepatic glucose production
- Stimulates the pancreas to release more insulin
- May reduce the need for higher doses of individual medications
Uses
Glucovance is indicated for:
- Management of type 2 diabetes mellitus in adults
- Patients whose blood sugar levels are not adequately controlled with diet and exercise alone
- As an adjunct to diet and lifestyle changes to improve glycemic control
Dosage and Administration
- Dosage must be individualized based on the patient’s response and medical advice
- Typically taken once or twice daily with meals to reduce gastrointestinal side effects
- Do not crush or chew tablets; swallow whole with water
Warnings and Precautions
- Not recommended for type 1 diabetes or diabetic ketoacidosis
- Use with caution in elderly patients and those with renal or hepatic impairment
- May cause hypoglycemia, especially when taken without food or with other anti-diabetic medications
- Avoid excessive alcohol consumption while on this medication
Possible Side Effects
- Nausea, vomiting, or stomach upset (especially at the beginning of treatment)
- Low blood sugar (hypoglycemia) symptoms such as dizziness, sweating, or shaking
- Rarely, lactic acidosis—a serious condition requiring urgent medical attention
Storage Instructions
- Store in a cool, dry place below 30°C
- Keep out of reach of children
- Do not use after the expiry date on the package
Note: Always use this medication under the supervision of a qualified healthcare provider. Regular monitoring of blood sugar levels is essential.