Paludrine 100MG X 98 contains the active ingredient Proguanil Hydrochloride which is an anti-malarial. Malaria is caused by various types of parasites known as plasmodium which are carried by mosquitoes and are injected into the bloodstream if an infected mosquito bites us. The parasite then invades our red blood cells and reproduces. A malaria attack occurs when the infected blood cells burst which releases a mass of parasites into the bloodstream. Proguanil Hydrochloride works by stopping the parasite from reproducing inside our blood cells. By blocking its production, proguanil prevents any malarial parasites that have entered the red blood cells from reproducing and causing malaria attacks. You must take this medication exactly as your doctor or pharmacist has instructed you. When you are taking this medicine to prevent malaria, you should also reduce the chances of being bitten by mosquitoes: You should start taking this medicine one week before you enter the malaria area. If this isn’t possible then you should start taking this medicine at least two days before you enter the malaria area. Continue to take Paludrine during your stay and keep taking it for 4 weeks after leaving the malaria area. Adults and children over 14 years – Take 2 tablets daily Children under 1 year (including babies who are being breast-fed) – take a quarter of a tablet daily Ages 1-4 years – Take half a Paludrine tablet daily Ages 5-8 years – Take one Paludrine tablet daily Ages 9-14 years – Take one and a half Paludrine tablets daily.